Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin

Beatty, Stephen and Nolan, John M and Kavanagh, H. and O'Donovan, O. M. (2004) Macular pigment optical density and its relationship with serum and dietary levels of lutein and zeaxanthin. Archives Of Biochemistry And Biophysics, 430 (1). pp. 70-76. ISSN 1096-0384

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Abstract

Observational evidence is accumulating that the onset of age-related maculopathy, the leading cause of legal blindness in the Western World, could be delayed, or even averted, with antioxidant supplements. Lutein (L) and zeaxanthin (Z) are two hydroxycarotenoids with antioxidant activity which accumulate at the macula, where they are collectively known as macular pigment (MP). It has been shown that MP is entirely of dietary origin, and that L and Z levels in serum, diet, and retina correlate. However, the nature of the relationships between L and Z in foodstuffs, blood, and macula is confounded by many variables including processes which influence digestion, absorption, and transport of the compounds in question, and accumulation and stabilization of the carotenoids in the tissues. If macular pigment is protective for age-related maculopathy, a clear understanding of the mechanisms whereby L and Z arrive at the target tissue (retina) from their source (foodstuff) is essential. In this paper, we review the literature germane to this growing area of interest. (C) 2004 Elsevier Inc. All rights reserved.

Item Type: Article
Additional Information: ISI Document Delivery No.: 851CQ English Article 0003-9861
Uncontrolled Keywords: age-related maculopathy carotenoids lutein zeaxanthin Beta-carotene oxidative stress alpha-tocopherol tissue concentrations human retina in-vitro plasma age supplementation absorption
Departments or Groups: Macular Pigment Research Group
Divisions: School of Science > Department of Chemical and Life Sciences
Date Deposited: 15 Nov 2007 20:36
Last Modified: 27 May 2022 12:27
URI: http://repository.wit.ie/id/eprint/13

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