Resistance exercise increases endothelial progenitor cells and angiogenic factors

Harrison, Michael (2014) Resistance exercise increases endothelial progenitor cells and angiogenic factors. Medicine and Science in Sports and Exercise.

[thumbnail of Resistance_Exercise_Increases_Endothelial.4.pdf]
Preview
Text
Resistance_Exercise_Increases_Endothelial.4.pdf

Download (1MB) | Preview

Abstract

ROSS, M. D., A. L. WEKESA, J. P. PHELAN, and M. HARRISON. Resistance Exercise Increases Endothelial Progenitor Cells and Angiogenic Factors. Med. Sci. Sports Exerc., Vol. 46, No. 1, pp. 16–23, 2014. Introduction: Bone marrow-derived endothelial progenitor cells (EPC) are involved in vascular growth and repair. They increase in the circulation after a single bout of aerobic exercise, potentially related to muscle ischemia. Muscular endurance resistance exercise (MERE) bouts also have the potential to induce muscle ischemia if appropriately structured. Purpose: The objective of this study is to determine the influence of a single bout of MERE on circulating EPC and related angiogenic factors. Methods: Thirteen trained men age 22.4 T 0.5 yr (mean T SEM) performed a bout of MERE consisting of three sets of six exercises at participants’ 15-repetition maximum without resting between repetitions or exercises. The MERE bout duration was 12.1 T 0.6 min. Blood lactate and HR were 11.9 T 0.9 mmolIL j1 and 142 T 5 bpm, respectively, at the end of MERE. Blood was sampled preexercise and at 10 min, 2 h, and 24 h postexercise. Results: Circulating EPC and serum concentrations of vascular endothelial growth factors (VEGF-A, VEGF-C, and VEGF-D), granulocyte colony stimulating factor, soluble Tie-2, soluble fms-like tyrosine kinase-1, and matrix metalloproteinases (MMP-1, MMP-2, MMP-3, MMP-9, and MMP-9) were higher (P G 0.05) in the postexercise period. Circulating EPC levels were unchanged at 10 min postexercise but higher at 2 h postexercise (P G 0.05). The concentration of most angiogenic factors and metalloproteinases were higher at 10 min postexercise (VEGF-A, +38%; VEGF-C, +40%; VEGF-D, +9%; soluble Tie-2, +15%; soluble fms-like tyrosine kinase-1, +24%; MMP-1, +62%; MMP-2, +3%; MMP-3, +54%; and MMP-9, +45%; all P G 0.05). Soluble E-selectin was lower (P G 0.05) at 2 and 24 h postexercise, with endothelial microparticles and thrombomodulin unchanged. Conclusions: Short intense bouts of MERE can trigger increases in circulating EPC and related angiogenic factors, potentially contributing to vascular adaptation and vasculoprotection. Key Words: VASCULAR ENDOTHELIAL GROWTH FACTOR, MATRIX METALLOPROTEINASE, MUSCULAR ENDURANCE, MUSCLE ISCHEMIA

Item Type: Article
Uncontrolled Keywords: VASCULAR ENDOTHELIAL GROWTH FACTOR, MATRIX METALLOPROTEINASE, MUSCULAR ENDURANCE, MUSCLE ISCHEMIA
Departments or Groups: Pharmaceutical and Molecular Biotechnology Research Centre > Biomedical Research Cluster
Divisions: School of Health Sciences > Department of Health, Sport and Exercise Studies
Depositing User: Michael Harrison
Date Deposited: 07 Mar 2014 09:34
Last Modified: 27 May 2022 13:34
URI: https://repository.wit.ie/id/eprint/2764

Actions (login required)

View Item View Item