Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions

Mardinoglu, Adil and Cregg, P. J. (2015) Modelling the Effect of SPION Size in a Stent Assisted Magnetic Drug Targeting System with Interparticle Interactions. The Scientific World Journal, 2015. ISSN 2356-6140

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Official URL: http://dx.doi.org/10.1155/2015/618658

Abstract

Cancer is a leading cause of death worldwide and it is caused by the interaction of genomic, environmental, and lifestyle factors. Although chemotherapy is one way of treating cancers, it also damages healthy cells and may cause severe side effects.Therefore, it is beneficial in drug delivery in the human body to increase the proportion of the drugs at the target site while limiting its exposure at the rest of body through Magnetic Drug Targeting (MDT). Superparamagnetic iron oxide nanoparticles (SPIONs) are derived from polyol methods and coated with oleic acid and can be used as magnetic drug carrier particles (MDCPs) in an MDT system. Here, we develop a mathematical model for studying the interactions between the MDCPs enriched with three different diameters of SPIONs (6.6, 11.6, and 17.8 nm) in the MDT system with an implanted magnetizable stent using different magnetic field strengths and blood velocities. Our computational analysis allows for the optimal design of the SPIONs enriched MDCPs to be used in clinical applications.

Item Type: Article
Departments or Groups: Materials Characterisation and Processing Group
Divisions: School of Engineering > Department of Engineering Technology
SWORD Depositor: Gary Robinson
Depositing User: P.J. Cregg
Date Deposited: 11 May 2015 10:29
Last Modified: 22 Aug 2016 10:27
URI: http://repository.wit.ie/id/eprint/3028

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