Molecular Communications Pulse-Based Jamming Model for Bacterial Biofilm Suppression

Martins, Daniel P. and Leetanasaksakul, Kantinan and Barros, Michael Taynnan and Thamchaipenet, Arinthip and Donnelly, William and Balasubramaniam, Sasitharan (2018) Molecular Communications Pulse-Based Jamming Model for Bacterial Biofilm Suppression. IEEE Transactions on NanoBioscience, 17 (4). pp. 533-542. ISSN 1536-1241

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Official URL: http://dx.doi.org/10.1109/TNB.2018.2871276

Abstract

Studies have recently shown that the bacteria survivability within biofilms is responsible for the emergence of superbugs. The combat of bacterial infections, without enhancing its resistance to antibiotics, includes the use of nanoparticles to quench the quorum sensing of these biofilm-forming bacteria. Several sequential and parallel multi-stage communication processes are involved in the formation of biofilms. In this paper, we use proteomic data from a wet lab experiment to identify the communication channels that are vital to these processes.We also identified the main proteins from each channel and propose the use of jamming signals from synthetically engineered bacteria to suppress the production of those proteins. This biocompatible technique is based on synthetic biology and enables the inhibition of biofilm formation. We analyse the communications performance of the jamming process, by evaluating the path loss for a number of conditions that include different engineered bacterial population sizes, distances between the populations and molecular signal power. Our results show that sufficient molecular pulsebased jamming signals are able to prevent the biofilm formation by creating lossy communications channels (almost -3 dB for certain scenarios). From these results, we define the main design parameters to develop a fully operational bacteria-based jamming system.

Item Type: Article
Departments or Groups: Telecommunications Software and Systems Group
Divisions: School of Science
Depositing User: Admin SSL
Date Deposited: 08 Apr 2019 15:47
Last Modified: 08 Apr 2019 16:15
URI: http://repository.wit.ie/id/eprint/3336

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