Monthly consistency of macular pigment optical density and serum concentrations of lutein and zeaxanthin

Nolan, J. M. and Stack, J. and Mellerio, J. and Godhinio, M. and O'Donovan, O. M. and Neelam, K. and Beatty, S. (2006) Monthly consistency of macular pigment optical density and serum concentrations of lutein and zeaxanthin. Current Eye Research, 31 (2). pp. 199-213.

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Abstract

Purpose: This study was undertaken to assess serial month-to-month consistency of macular pigment (MP) optical density and serum concentrations of lutein (L) and zeaxanthin (Z). Four healthy subjects aged between 23 and 51 years volunteered to participate in this study. Methods: MP optical density (measured psychophysically using heterochromatic flicker photometry [HFP]), and serum concentrations of L and Z (quantified using high-performance liquid chromatography [HPLC]), were recorded every month for 24 consecutive months. Results: Mean MP optical density (SD) was 0.361 (0.086) and 0.369 (0.074) for right and left eyes, respectively. There was no statistically significant seasonal variation in MP optical density for the group (two-way ANOVA: p > 0.05). Serum concentrations of L and Z demonstrated a statistically significant subject-season interaction effect (two-way ANOVA: p p < 0.05). There was no obvious relationship, synchronous or lagged, between serum concentrations of L (or Z) and MP optical density (r = -0.036 to 0.368). Conclusions: MP optical density was relatively stable for all subjects over the 24-month period. Fluctuations in serum concentrations of L and Z, in the absence of dietary modification or supplementation, are associated with stable MP optical density.

Item Type: Article
Additional Information: ISI Document Delivery No.: 015LO English Article 0271-3683
Uncontrolled Keywords: age-related macular degeneration lutein macular pigment stability temporal zeaxanthin Heterochromatic flicker photometry carotenoid concentrations tissue concentrations dietary modification european population seasonal-variation alpha-tocopherol primate retinas degeneration plasma
Departments or Groups: Macular Pigment Research Group
Divisions: School of Science
Date Deposited: 15 Jul 2009 10:43
Last Modified: 13 Mar 2017 12:35
URI: http://repository.wit.ie/id/eprint/63

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