Calculation of nanoparticle capture efficiency in magnetic drug targeting

Cregg, P J and Murphy, Kieran and Mardinoglu, Adil Calculation of nanoparticle capture efficiency in magnetic drug targeting. Journal of Magnetism and Magnetic Materials. (Submitted)

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Abstract

The magnetic targeted drug delivery system of Aviles, Ebner and Ritter, which uses high gradient magnetic separation (HGMS) is considered. In that model large ferromagnetic particles are used as seeds to aid collection of multiple domain nanoparticles (radius ≈ 200nm. Here, in contrast, single domain magnetic nanoparticles(radius in 20–100 nm) are considered and the Langevin function is used to describe the magnetization. Simulations based on this model were performed using the open source C++ finite volume library OpenFOAM. The simulations indicate that use ofthe Langevin function predicts greater collection efficiency than might be otherwise expected.

Item Type: Article
Departments or Groups: Materials Characterisation and Processing Group
Divisions: School of Science > Department of Computing, Maths and Physics
School of Engineering > Department of Engineering Technology
Depositing User: P.J. Cregg
Date Deposited: 01 Feb 2008 09:38
Last Modified: 22 Aug 2016 10:25
URI: http://repository.wit.ie/id/eprint/910

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